منابع مشابه
Preclinical Research into Basic Mechanisms of Radiation-Induced Heart Disease
Radiation-induced heart disease (RIHD) is a potentially severe side effect of radiotherapy of thoracic and chest wall tumors if all or part of the heart was included in the radiation field. RIHD presents clinically several years after irradiation and manifestations include accelerated atherosclerosis, pericardial and myocardial fibrosis, conduction abnormalities, and injury to cardiac valves. T...
متن کاملBasic mechanisms in apoptosis and heart failure
The syndrome of heart failure may arise from different causes but there are features that are common to all: myocardial fibrosis, desensitization of b-adrenergic receptor signalling, excitation-contraction uncoupling, myosin isoform switch, altered energy utilization and ‘‘cell loss’’. These unifying features imply that the molecular pathways that underpin them are activated in most, if not all...
متن کاملBasic Mechanisms and Implications for Cardiovascular Disease
Apoptosis : Basic Mechanisms and Implications for Cardiovascular Disease Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 1998 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/01.RES.82.11.1111 1998;82:1111-1129 Circ Res. http://circres.ahajournals.org/content...
متن کاملMolecular mechanisms of diabetic kidney disease.
Diabetic kidney disease (DKD) is the leading cause of kidney failure worldwide and the single strongest predictor of mortality in patients with diabetes. DKD is a prototypical disease of gene and environmental interactions. Tight glucose control significantly decreases DKD incidence, indicating that hyperglycemia-induced metabolic alterations, including changes in energy utilization and mitocho...
متن کاملDiabetic Myopathy and Mechanisms of Disease
Humans build muscle mass over the first two decades of life; begin to lose muscle mass and strength between the third and fourth decades, and the decline accelerates during the sixth decade [1,2]. Sarcopenia and dynapenia are age-related loss of skeletal muscle mass and muscle strength, respectively [1–3]. Loss of muscle mass and strength are associated with a reduction in vitality, manifested ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2020
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.120.315913